Human cop1

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August undefined, 2024

WebDysregulation of miR23-5p was reported in various human diseases, such as ischemia-reperfusion injury, coronary heart diseases, and cancers . For these reasons, miR23-5p was extensively studied in different types of human cancers, where it can play various roles in the initiation, progression and maintenance of cancer cells [ 98 ]. Web25 mei 2024 · COP1, an E3 ubiquitin ligase, targets myriads of proteins for ubiquitination and degradation. It primarily targets transcription factors involved in photomorphogenesis, such as HY5, LAF1, and several B-BOX (BBX) proteins, among others ( Osterlund et al., 2000 ; Lau and Deng, 2012 ).

Role of the COP1 protein in cancer development and therapy

Web27 jan. 2024 · Focal deletions of COP1 were observed at significant frequency across several cancer types, and COP1 loss was determined to be one of the mechanisms leading to c-Jun upregulation in human cancer. We therefore conclude that Cop1 is a tumor suppressor that functions, at least in part, by antagonizing c-Jun oncogenic activity. WebCOP1 Name Type symbol Gene Model Type protein_coding Aliases AJ000535; AJ000536; L24437 Description Represses photomorphogenesis and induces skotomorphogenesis in the dark. Contains a ring finger zinc-binding motif, a coiled-coil domain, and several WD-40 repeats, similar to G-beta proteins. proof order system for southern glazers

64326 - Gene ResultCOP1 COP1 E3 ubiquitin ligase

WebDepartment of Work and Pensions. May 2016 - Present7 years. Birmingham, United Kingdom. Working for the Civil Service as Decision Maker on the Employment Allowance Support cases. Applying the relevant Social Security legislation and regulations to make decisions. Evaluating the evidence. Considering the merits of the appeals made by the … WebThe bimolecular complex formed by the tumor suppressor p53 and the ubiquitin ligase COP1, topographically visualized on a mica substrate, is characterized by a surprisingly high specificity and affinity, both at the single-molecule level and in bulk solution. We note that the p53–COP1 interaction is characterized by a higher affinity and by a ... Web8 dec. 2024 · COP1 regulates human breast cancer cell proliferation and apoptosis in a p53-dependent manner.The COP1-mediated degradation of p53 regulates cancer cell … proof orders coupon

COP1 Gene - GeneCards COP1 Protein COP1 Antibody

COP1 is a tumour suppressor that causes degradation of ETS ...

WebIntroduction. In plant, COP1 is a crucial mediator to block Photomorphogenesis during dark through ubiquitin mediated proteasomal degradation of light-induced transcription factor Hypocotyl 5 (HY5) Hardtke et al., 2000.Human constitutive photomorphogensis protein 1 (huCOP1= “COP1”) E3 ubiquitin ligase, is reportedly overexpressed in breast, ovarian … WebCOP1 is found not only in plants, but also in vertebrates, where it plays a role in the degradation of transcription factors such as p53 and the c-Jun protein . Interestingly, … proof oranges are maleWebDetection of human COP1/RFWD2 by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-COP1/RFWD2 antibody A300-894A (lot A300-894A-2) used for IP at 6 µg per reaction. lack of breath medical term

"Web30 mei 2003 · Human COP1 shows a high degree of sequence conservation and domain organization with its plant counterpart. We found that transfected huCOP1 distributed to the cytoplasm and the nucleus of cells and that nuclear localization was directed by a NLS located in the amino-terminal region of the protein. " - Human cop1

Human cop1

COP1, the Negative Regulator of p53, Is Overexpressed in Breast …

WebPostdoctoral Fellow in Plant Molecular Biology. apr. 2024 - heden1 maand. Utrecht, Utrecht, Netherlands. As a post-doctoral researcher at Utrecht University, I have recently begun investigating the circadian clock and plant development, utilizing advanced biology techniques to explore the underlying mechanisms of these processes. Web29 jan. 2024 · The human TRIB1 coding sequence was synthesized by GenScript. Human cDNAs for COP1, C/EBPα, and DET1 were purchased from transOMIC (BC094728, BC160133, BC109060). Constructs for each of these proteins were cloned into pcDNA3.1(+). 3xFLAG-CRM1 was a gift from Xin Wang (Addgene plasmid #17647). …

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Web1 dec. 2024 · COP1 was originally identified as a central negative regulator of photomorphogenesis in Arabidopsis thaliana [20,21]. COP1 exists in non-plant … Web概述产品名称 Anti-COP1抗体 [1E4] 参阅全部 COP1 一抗描述小鼠单克隆抗体 [1E4] to COP1 宿主 Mouse 经测试应用适用于: WB, ICC/IF, IHC-P, Flow Cyt more details 种属反应性与反应: Mouse, Human 免疫原 Recombinant fragment: CLRSFKGHIN EKNFVGLASN GDYIACGSEN NSLYLYYKGL SKTLLTFKFD TVKSVLDKDR KEDDTNEFVS …

Webenabling COP1 to play a crucial role in different photoreceptor pathways in plants. RESULTS The COP1 WD40 domain binds VP motifs from UVR8 and HY5 The WD40 domains of human and Arabidopsis COP1 can directly sense VP-containing peptides (Uljon et al., 2016). Such a VP-peptide motif can be found in the UVR8 C-terminus that is not part WebCOP1 is significantly overexpressed in 81% of breast and 44% of ovarian adenocarcinomas. 79 Furthermore, in human hepatocellular carcinoma cells, silencing COP1 inhibits proliferation and induces apoptosis. 80 Also, the role of COP1 as a negative modulator of p53 is a strong argument for its tumor-promoting actions. 59 COP1 overexpression in …

WebSupporting: 1, Mentioning: 4 - ONE SENTENCE SUMMARY:A Tribbles 2 pseudokinase small molecule screen led to the identification of known EGFR/HER2 inhibitors that alter the stability of TRIB2 in vitro and lead to rapid on-target degradation of TRIB2 in human cancer cells. SHORT ABSTRACT: (150 words)Tribbles 2 (TRIB2) is a cancer-associated … WebCOP1 thus serves as a critical regulator of hepatocyte TAG content, fatty acid mobilization, and oxidation. Moreover, COP1-mediated regulation of hepatic lipid metabolism requires …

Web13 apr. 2024 · During COP1, it was also decided that an ad hoc working group on human rights defenders in environmental matters would be established. This is an opportunity for public participation, including for Indigenous Peoples, at the annual forum on Human Rights Defenders in Environmental Matters in Latin America and the Caribbean.

Web15 mei 2011 · a, COP1 DNA copy number in human prostate cancers. The dashed green line indicates the cutoff for copy number loss (log 2 ratio ≤ −0.3). 5/166 tumours exhibit … lack of buckleWebCOP1 is an evolutionarily conserved RING-finger ubiquitin ligase acting within a Cullin-RING ligase (CRL) complex that promotes polyubiquitination of c-Jun and p53. Stability of the above substrates is affected by … lack of brains vs brawnsWebCop1 - Solidarités Étudiantes. août 2024 - aujourd’hui9 mois. Ville de Paris, Île-de-France, France. Chargée de l’organisation de collectes au sein de magasins, entreprises, universités et lycées. - Supervision d’une équipe d’une quinzaine de bénévoles. - Prise de contact avec les magasins et autres partenaires. lack of brains hinders researchWeb1 jul. 2014 · COP1 and members of the four SPA proteins are part of an E3 ubiquitin ligase that acts in darkness to ubiquitinate several transcription factors involved in light responses, thereby targeting them for degradation by the proteasome. While COP1 is also found in humans, SPA proteins appear specific to plants. lack of budget synonymsWeb15 mei 2011 · COP1 Is a Tumour Suppressor That Causes Degradation of ETS Transcription Factors. The proto-oncogenes ETV1, ETV4 and ETV5 encode transcription … lack of building codesWebo Destination of COP1 vesicles moving retrograde. Golgi cisternae; o Constitutes majority of the organelle o Divided into three main sections: cis, medial, and trans o Site of Golgi metabolism – synthesis of polysaccharides used to glycosylate proteins and lipids. trans Golgi network (TGN) lack of brain functionWebAbout. Medical Drug Development, New Drug Development, Generic Drug Development, Virology, Mutants, CAPD Concomitant Ambulatory Peritoneal Dialysis (CAPD). It started at WITS U, went to Berlin 1981 and changed the world. J.D. Block & K. Furman International Proceedings on Peritoneal Dialysis June 16-18, 1981. proof ordering southern