WebSeveral methuosis inducers have been reported, for example, indole-based chalcones MIPP and MOMIPP triggered cell death by methuosis in glioblastoma [10, 11]; an ursolic acid derivative led cell death via methuosis [12]; a 4,6-disubstituted Aza-indole compound 13 induced methuosis and displayed cytotoxicities against a panel of cancer cells [13]; … WebUniversity of Vienna. Okt. 2015–Heute7 Jahre 7 Monate. Vienna. Fellowship Programme, co-funded by the EU Framework programme 7 (FP7) Marie Curie Actions. Funded Project: 'Resensitisation of chemotherapy resistant cancer cells through selective inhibition of the STAT3 signalling pathway'. • Drug-Discovery, biological evaluation and ...

Frontiers The Dual Role of Macropinocytosis in Cancers: …

WebMethuosis inducer 1 is a potent methuosis inducer, with nticancer activity. 体内活性. Methuosis inducer 1 exhibited substantial pharmacological efficacy in the suppression of … WebAbstract: Methuosis has been described as a distinctive form of cell death characterized by the displacement of large fluid-filled vacuoles derived from uncontrolled macropinocytosis. Its induction has been proposed as a new strategy against cancer cells. is a bunny considered a rodent

"Janus" efficacy of CX-5011: CK2 inhibition and methuosis ... - Pub…

WebMethuosis is a novel nonapoptotic mode of cell death characterized by vacuole accumulation in the cytoplasm. In this report, we describe a series of azaindole-based … Web19 jun. 2024 · Methuosis is a novel nonapoptotic mode of cell death characterized by vacuole accumulation in the cytoplasm. In this article, we describe a series of azaindole-based compounds that cause vacuolization in MDA-MB-231 cells. WebAspects of the present invention relate to the use the growth factors such as e.g., cytokines IL-2 and IL-12 for T-cell activation whereby the growth factor(s) is/are expressed by cells comprising synthetic chromosomes. The growth factor(s) is/are desirably under controllable expression from a synthetic chromosome. By approaches described herein, one can … is a buret tc or td