WebImaging tests. Imaging tests can help your doctor see your internal organs and look for signs of cholangiocarcinoma. Techniques used to diagnose bile duct cancer include ultrasound, computerized tomography (CT) scans and magnetic resonance imaging (MRI) combined … WebMar 14, 2024 · Cholangiocarcinoma may be asymptomatic in the early stages. Classic symptoms of painless jaundice, weight loss, and abdominal pain usually appear in advanced disease. Liver enzymes, blood levels of carbohydrate antigen (CA) 19-9, carcinoembryonic antigen, CA-125; abdominal ultrasound, abdominal CT/MRI, and endoscopic ultrasound for …
Immunohistochemistry for Diagnosis of Metastatic Carcinomas of …
WebMar 9, 2024 · As TTF1 negativity can cause difficulties in the proper diagnosis of lung cancer, additional markers are needed. A useful marker is SMARCA4, as the more aggressive TTF1-negative lung cancers frequently show loss in the IHC because of a genomic alteration in the SMARCA gene [21, 22]. WebAug 29, 2024 · Keratin 19 may be the most useful cytokeratin for distinguishing HCC from intrahepatic cholangiocarcinoma: AFP: Weak staining with high background (30%) Theoretically negative in most tumors other than germ cell tumors: Poor staining quality limits utility of AFP staining: TTF1: Cytoplasmic staining of HCC with some TTF1 clones … patricia toffoli
The role of TTF-1 in differentiating primary and metastatic lung
WebAug 1, 2024 · Cholangiocarcinoma has been considered a diagnosis of exclusion and extensive clinical and imaging work-up has been necessary before this diagnosis can be made. The presence of cholangiolar pattern and positive albumin on in situ hybridization … WebThe diagnosis of hepatocellular carcinoma (HCC) remains obscure in some complicated cases. Thyroid transcription factor-1 (TTF-1) was presumed to be helpful in the diagnosis of HCC. This paper aims to study the utility of TTF-1 in the diagnosis and differential … WebMar 20, 2024 · The prognosis of advanced or metastatic cholangiocarcinoma is extremely unsatisfactory, mainly owing to few treatment options and poor responses to conventional chemotherapy regimens.1 Since 2007, advances in next-generation sequencing have substantially improved the ability to understand the complex molecular mechanisms … patricia todd md dermatology